Abstract |
The effect of nedocromil sodium on the main sensory nerve types in the dog lung has been studied. Nedocromil sodium (0.1, 1.0 and 10 mg/kg i.v.) did not stimulate or inhibit the discharge pattern of pulmonary stretch receptors, rapidly adapting irritant receptors or pulmonary C-fibre endings. Nedocromil sodium 5 micrograms/kg given into the aortic arch did, however, stimulate bronchial C-fibre endings. These endings were also stimulated when the drug was given by aerosol. The possibility that nedocromil sodium suppresses cough in the dog by stimulation of bronchial C-fibre endings is discussed.
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Authors | D M Jackson, A A Norris, R P Eady |
Journal | Pulmonary pharmacology
(Pulm Pharmacol)
Vol. 2
Issue 4
Pg. 179-84
( 1989)
ISSN: 0952-0600 [Print] England |
PMID | 2562474
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Irritants
- Quinolones
- Nedocromil
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Body Temperature
(drug effects)
- Dogs
- Female
- Irritants
(pharmacology)
- Lung
(drug effects, innervation)
- Male
- Mechanoreceptors
(drug effects)
- Myelin Sheath
(physiology)
- Nedocromil
- Nerve Endings
(drug effects)
- Nerve Fibers
(drug effects)
- Neurons, Afferent
(drug effects)
- Quinolones
(pharmacology)
- Stimulation, Chemical
- Vagus Nerve
(physiology)
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