Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications.

Abstract

Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with (125)I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33-35°C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors.

• Authors: Peter Černoch, Zulfiya Černochová, Jan Kučka, Martin Hrubý, Svetlana Petrova, Petr Štěpánek
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 98 Pg. 7-12 (Apr 2015) ISSN: 1872-9800 [Electronic] England
• PMID: 25617711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Biocompatible Materials
• Iodine Radioisotopes
• Methacrylates
• N-methacryloyl tyrosinamide
• Polymers
• Water
• poly-N-vinylcaprolactam
• Tyrosine
• Caprolactam

Topics

• Biocompatible Materials (chemistry)
• Brachytherapy (methods)
• Caprolactam (analogs & derivatives, chemistry)
• Humans
• Iodine Radioisotopes (therapeutic use)
• Materials Testing
• Methacrylates (chemistry)
• Neoplasms (radiotherapy)
• Polymers (chemistry)
• Solubility
• Temperature
• Tyrosine (analogs & derivatives, chemistry)
• Water