Coronary vasospasm secondary to 5-Fluorouracil and its management: case report.

Abstract

Although rare, 5-fluorouracil (5-FU) may lead to cardiotoxicity that presents with angina, elevated cardiac enzymes and electrocardiogram (ECG) changes. Coronary vasospasm related to 5-FU is a rare clinical entity in oncological practice and may be seen during both bolus and protracted infusional administration. This toxicity is generally reversible and responds well to conventional anti-angina treatment following discontinuation of infusion. We propose that parenteral diltiazem is an effective and safe approach for the treatment of coronary vasospasm secondary to 5-FU infusion. We present clinical findings and management of a case in which coronary vasospasm occurred during the infusion of the 5-FU component of FOLFIRI-bevacizumab chemotherapy (CT) regimen given for treatment of metastatic rectal cancer.

• Authors: Mustafa Yildirim, Cem Parlak, Cem Sezer, Ramazan Eryilmaz, Cetin Kaya, Mustafa Yildiz
• Journal: The Eurasian journal of medicine (Eurasian J Med) Vol. 43 Issue 1 Pg. 54-6 (Apr 2011) ISSN: 1308-8734 [Print] Turkey
• PMID: 25610161 (Publication Type: Case Reports)