Toxic Epidermal Necrolysis During Dronedarone Treatment: First Report of a Severe Serious Adverse Event Of A New Antiarrhythmic Drug.

Abstract

A 77-year-old female patient with symptomatic atrial fibrillation with fast ventricular rate despite conventional antiarrhythmic therapy was treated with dronedarone. Five days later, she developed a maculopapulous exanthema and small flaccid blisters, which spread over the common integument predominantly located on the dorsal trunk. Over few days, the patient showed a severe epidermal necrolysis of approximately 30 % of the body area and ultimately died in multiorgan failure. Here, we report a rare case of toxic epidermal necrolysis during treatment with dronedarone leading to patient death.

• Authors: Thomas Gecks, Dirk Prochnau, Marcus Franz, Christian Jung, Helmut Kühnert, Sibylle Schliemann, Hans Rainer Figulla
• Journal: Cardiovascular toxicology (Cardiovasc Toxicol) Vol. 15 Issue 4 Pg. 399-401 (Oct 2015) ISSN: 1559-0259 [Electronic] United States
• PMID: 25588686 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Dronedarone
• Amiodarone

Topics

• Aged
• Amiodarone (adverse effects, analogs & derivatives)
• Anti-Arrhythmia Agents (adverse effects)
• Atrial Fibrillation (diagnosis, drug therapy, physiopathology)
• Biopsy
• Dronedarone
• Fatal Outcome
• Female
• Heart Rate (drug effects)
• Humans
• Multiple Organ Failure (chemically induced)
• Severity of Illness Index
• Stevens-Johnson Syndrome (diagnosis, etiology)
• Time Factors