Abstract | OBJECTIVE: APPROACH AND RESULTS: Blood samples were obtained from 4122 patients (median age, 62 years; 72% men) who underwent elective coronary angiography. During median follow-up of 56 months, 8.3% had acute myocardial infarction. Comparing the highest quartile to the lowest, for the total cohort, multivariable adjusted hazard ratios (95% confidence intervals) were 1.68 (1.21-2.34), 1.81 (1.33-2.48), 1.68 (1.21-2.32), and 1.48 (1.10-1.99) for kynurenic acid, hydroxykynurenine, anthranilic acid, and hydroxyanthranilic acid, respectively. The kynurenines correlated with phenotypes of the metabolic syndrome, and risk associations were generally stronger in subgroups classified with pre- diabetes mellitus or diabetes mellitus at inclusion (Pint≤0.05). Evaluated in the total population, hydroxykynurenine and anthranilic acid provided statistically significant net reclassification improvements (0.21 [0.08-0.35] and 0.21 [0.07-0.35], respectively). CONCLUSIONS:
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Authors | Eva Ringdal Pedersen, Nora Tuseth, Simone J P M Eussen, Per Magne Ueland, Elin Strand, Gard Frodahl Tveitevåg Svingen, Øivind Midttun, Klaus Meyer, Gunnar Mellgren, Arve Ulvik, Jan Erik Nordrehaug, Dennis W Nilsen, Ottar Nygård |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 35
Issue 2
Pg. 455-62
(Feb 2015)
ISSN: 1524-4636 [Electronic] United States |
PMID | 25524770
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 American Heart Association, Inc. |
Chemical References |
- Biomarkers
- Xanthurenates
- ortho-Aminobenzoates
- anthranilic acid
- Kynurenine
- xanthurenic acid
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Topics |
- Aged
- Angina, Stable
(blood, diagnosis, epidemiology, mortality)
- Biomarkers
(blood)
- Coronary Angiography
- Coronary Artery Disease
(blood, diagnosis, epidemiology, mortality)
- Diabetes Mellitus, Type 2
(blood, epidemiology)
- Female
- Humans
- Incidence
- Kynurenine
(blood)
- Linear Models
- Logistic Models
- Male
- Metabolic Syndrome
(blood, epidemiology)
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(blood, diagnosis, epidemiology, mortality)
- Norway
(epidemiology)
- Prediabetic State
(blood, epidemiology)
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Risk Assessment
- Risk Factors
- Up-Regulation
- Xanthurenates
(blood)
- ortho-Aminobenzoates
(blood)
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