Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis.

Abstract

BACKGROUND:

Paraoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment.

METHODS:

A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated.

RESULTS:

In the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively).

CONCLUSION:

Low serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.

• Authors: Ali Annagür, Rahmi Örs, Hüseyin Altunhan, Sevil Kurban, Sabahattin Ertuğrul, Murat Konak, Saime Sündüz Uygun, Sevgi Pekcan, Ekrem Erbay, İdris Mehmetoğlu
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 57 Issue 4 Pg. 608-13 (Aug 2015) ISSN: 1442-200X [Electronic] Australia
• PMID: 25488411 (Publication Type: Journal Article)
• Copyright: © 2014 Japan Pediatric Society.

Chemical References

• Antioxidants
• Biomarkers
• Oxidants
• Aryldialkylphosphatase

Topics

• Antioxidants (metabolism)
• Aryldialkylphosphatase (blood)
• Biomarkers (blood)
• Female
• Humans
• Infant, Newborn
• Male
• Neonatal Sepsis (blood)
• Oxidants (blood)
• Oxidative Stress
• Retrospective Studies