Anti-hyperglycemic and anti-hyperlipidemic potential of a polyherbal preparation "Diabegon" in metabolic syndrome subject with type 2 diabetes.

Abstract

BACKGROUND:

In the present study, "Diabegon" a poly-herbal preparation, with hypoglycemic activity, was evaluated for its preventive effect in metabolic syndrome subjects with type 2 diabetes and also to reveal its side effects, on liver and kidney.

MATERIALS AND METHODS:

Type 2 diabetic subjects with metabolic syndrome (N=58) were categorized on the basis of age and fasting blood glucose. The grouping was as follows: Group I (35-50 yrs), Group II (51-65 yrs), Group III >65 yrs, Group IV FBS<145.9, Group V FBS>145. Each group was administered 4 gm of diabegon daily. Blood glucose levels, lipid profile, liver and kidney function of the subjects were regularly monitored within 3 months of interval to 18 months.

RESULTS:

The reduction in fasting blood glucose level ranged from 12.3% (P<0.05) to 42% (P<0.001) after 18 month of therapy whereas in postprandial blood glucose, the decrease ranged from 28% (P<0.05) to 32% (P<0.05) after 18 month of therapy. Overall reductions in the individual parameters of the metabolic syndrome subjects were significantly higher in Group I. Cholesterol level decreased from 11% to 27.2% (P<0.001), triglyceride levels decreased from 24% to 55%, VLDL and LDL levels reduced by 60% & 54% respectively after 18 months of therapy. The HDL-C level increased in all groups. Moreover, diabegon administration for 1.5 years exhibited no alteration in liver and kidney function tests, which indicate its non-toxicity.

CONCLUSION:

Our study suggests that diabegon could be included as a preventive treatment in metabolic syndrome subjects with type 2 diabetes especially for long term treatment as it efficiently shows anti-hyperglycemic and anti-lipidemic effects with no adverse impacts on the liver and kidney.

• Authors: Dhananjay Yadav, Arvind Tiwari, Meerambika Mishra, Senthil S Subramanian, Usha Singh Baghel, Sunil Mahajan, P S Bisen, G B K S Prasad
• Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM (Afr J Tradit Complement Altern Med) Vol. 11 Issue 2 Pg. 249-56 ( 2014) ISSN: 2505-0044 [Electronic] Nigeria
• PMID: 25435604 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Plant Extracts

Topics

• Adult
• Aged
• Antihypertensive Agents (administration & dosage, adverse effects)
• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (administration & dosage, adverse effects)
• Kidney (drug effects, metabolism)
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Male
• Metabolic Syndrome (drug therapy, metabolism)
• Middle Aged
• Plant Extracts (administration & dosage, adverse effects)