Label-free detection of Alzheimer's disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide.

Abstract

The early diagnosis of Alzheimer's disease (AD) is challenging due to the lack of reliable methods for detecting its biomarkers in the noninvasive biopsies. We used surface plasmon resonance imaging to identify AD based on the detection of amyloid-beta42 in the serum by the ADP3 peptoid.

• Authors: Zijian Zhao, Ling Zhu, Xiangli Bu, Huailei Ma, Shu Yang, Yanlian Yang, Zhiyuan Hu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 4 Pg. 718-21 (Jan 14 2015) ISSN: 1364-548X [Electronic] England
• PMID: 25418132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• Peptoids
• amyloid beta-protein (1-42)

Topics

• Alzheimer Disease (blood, diagnosis)
• Amyloid beta-Peptides (blood)
• Equipment Design
• Humans
• Peptide Fragments (blood)
• Peptoids (chemistry)
• Surface Plasmon Resonance (instrumentation)