Abstract | BACKGROUND/AIM: There have been several attempts to treat delayed replantation with agents that inhibit root resorption. The purpose of this study was to assess the effectiveness of cathepsin K inhibitor in inhibiting osteoclastic activity compared to that of alendronate and enamel matrix protein. MATERIALS AND METHODS: RESULTS: Of all tested agents, Emdogain resulted in the least cytotoxicity on RAW 264.7 cells, while 10(-9) M odanacatib had the largest suppressive effects on the expression levels of inflammatory cytokines. CONCLUSIONS:
Odanacatib inhibits osteoclastic activity, showing the possibility as a treatment agent for delayed replantation of avulsed teeth.
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Authors | Wonkyung Yang, Hyunjung Ko, Heesun Kim, Miri Kim |
Journal | Dental traumatology : official publication of International Association for Dental Traumatology
(Dent Traumatol)
Vol. 31
Issue 3
Pg. 202-8
(Jun 2015)
ISSN: 1600-9657 [Electronic] Denmark |
PMID | 25394885
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Biphenyl Compounds
- Dental Enamel Proteins
- Interleukin-1beta
- Interleukin-6
- Lipopolysaccharides
- RANK Ligand
- Tumor Necrosis Factor-alpha
- enamel matrix proteins
- Cathepsin K
- Dinoprostone
- odanacatib
- Alendronate
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Topics |
- Alendronate
(pharmacology)
- Animals
- Biphenyl Compounds
(pharmacology)
- Cathepsin K
(antagonists & inhibitors)
- Cells, Cultured
- Dental Enamel Proteins
(pharmacology)
- Dinoprostone
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Interleukin-1beta
(metabolism)
- Interleukin-6
(metabolism)
- Lipopolysaccharides
- Mice
- Osteoclasts
(drug effects)
- RANK Ligand
(pharmacology)
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha
(metabolism)
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