Abstract | OBJECTIVE: Mechanisms of the dentigerous cyst formation from the normal eruption follicle is unknown but disturbances in the proteolytic activity have been suspected, since the growth of these cysts is accompanied by local bone destruction. The aim of the present study was to evaluate the expression of matrix metalloproteinases ( MMP) in human dental dentigerous cysts and healthy dental follicles. MATERIALS AND METHODS: RESULTS: MMP-8 was expressed slightly more in cyst epithelium than in odontogenic epithelium of healthy controls dental follicle but the difference lacked statistical difference. Other MMPs and TIMP-1 did not differ regarding the studied specimens. CONCLUSION: Differences in MMP expression cannot solely explain the cyst expansion suggesting the potential involvement of other osteolytic mechanisms.
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Authors | Juho Suojanen, Niko Lehtonen, Esa Färkkilä, Jarkko Hietanen, Olli Teronen, Timo Sorsa, Jaana Hagström |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 8
Issue 9
Pg. ZC82-5
(Sep 2014)
ISSN: 2249-782X [Print] India |
PMID | 25386530
(Publication Type: Journal Article)
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