Corilagin Protects Against HSV1 Encephalitis Through Inhibiting the TLR2 Signaling Pathways In Vivo and In Vitro.
| Abstract |
In this study, we tried to explore the molecular mechanism that Corilagin protected against herpes simplex virus-1 encephalitis through inhibiting the TLR2 signaling pathways in vivo and in vitro. As a result, Corilagin significantly prevented increase in the levels of TLR2 and its downstream mediators following Malp2 or HSV-1 challenge. On the other hand, in spite of TLR2 knockdown, Corilagin could still significantly suppress the expression of P38 and NEMO, phosphor-P38, and nuclear factor kappa B. The mRNA and protein expression of TLR2 and its downstream mediators in the brain tissue were also significantly lowered in mice treated with Corilagin. In addition, Corilagin inhibited expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 protein. In conclusion, Corilagin shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways. |
| Authors | Yuan-Jin Guo, Tao Luo, Fei Wu, Huan Liu, Hua-Rong Li, Yuan-Wu Mei, Shu-Ling Zhang, Jun-Yan Tao, Ji-Hua Dong, Yuan Fang, Lei Zhao |
| Journal | Molecular neurobiology
(Mol Neurobiol)
Vol. 52
Issue 3
Pg. 1547-1560
(Dec 2015)
ISSN: 1559-1182 [Electronic] United States |
| PMID | 25367881
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antiviral Agents
- Glucosides
- Hydrolyzable Tannins
- Interleukin-6
- Intracellular Signaling Peptides and Proteins
- Lipopeptides
- Membrane Glycoproteins
- Myd88 protein, mouse
- Myeloid Differentiation Factor 88
- NEMO protein, mouse
- NF-kappa B
- Nerve Tissue Proteins
- RNA, Messenger
- RNA, Small Interfering
- Receptors, Interleukin-1
- TIRAP protein, mouse
- TNF Receptor-Associated Factor 6
- Tlr2 protein, mouse
- Toll-Like Receptor 2
- Tumor Necrosis Factor-alpha
- interleukin-6, mouse
- corilagin
- macrophage stimulatory lipopeptide 2
- p38 Mitogen-Activated Protein Kinases
|
| Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Brain
(metabolism, pathology)
- Cells, Cultured
- Down-Regulation
(drug effects)
- Encephalitis, Herpes Simplex
(prevention & control)
- Glucosides
(pharmacology)
- Herpesvirus 1, Human
- Hydrolyzable Tannins
(pharmacology)
- Interleukin-6
(biosynthesis, genetics)
- Intracellular Signaling Peptides and Proteins
(biosynthesis, genetics)
- Lipopeptides
(toxicity)
- Male
- Membrane Glycoproteins
(biosynthesis, genetics)
- Mice
- Mice, Inbred BALB C
- Microglia
(drug effects, metabolism)
- Myeloid Differentiation Factor 88
(biosynthesis, genetics)
- NF-kappa B
(biosynthesis, genetics)
- Nerve Tissue Proteins
(biosynthesis, genetics)
- Phosphorylation
(drug effects)
- Protein Processing, Post-Translational
(drug effects)
- RNA Interference
- RNA, Messenger
(biosynthesis, genetics)
- RNA, Small Interfering
(genetics)
- Receptors, Interleukin-1
(biosynthesis, genetics)
- Signal Transduction
(drug effects)
- TNF Receptor-Associated Factor 6
(biosynthesis, genetics)
- Toll-Like Receptor 2
(antagonists & inhibitors, biosynthesis, genetics)
- Tumor Necrosis Factor-alpha
(biosynthesis, genetics)
- p38 Mitogen-Activated Protein Kinases
(genetics, metabolism)
|
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