[Hepatoprotective effect of Hypecoum erectum extract on experimental D-galactosamine-induced damage of rat liver].

Abstract

Hepatoprotective properties of the extract derived from the herbs of Hypecoum erectum L. have been studied on a model of D-galactosamine-induced hepatitis in rats. It is established that Hypecoum erectum extract in a dose of 50 mg/kg diminishes the development of cytolysis and cholestasis syndromes, as manifested by maximum decrease in the following indices after 7 days of the experiment: ALT activity by 26%; AST activity by 44%; alkaline phosphatase activity by 30%; β-lipoproteins by 21%; and bilirubin by 29% (p < 0.05). The Hypecoum erectum extract (i) increases the energy potential of hepatocytes, manifested by increasing the ATP content by 70% (p = 0.001) and normalizing the ratio of lactate and pyruvate in the liver homogenate; (ii) inhibits lipid peroxidation, manifested by decreasing the content of malonic dialdehyde in the liver homogenate and diene conjugates in the blood serum on the average by 30% (p < 0.05); (iii) activates the antioxidant system of the organism, increasing the catalase activity in liver homogenates by 58% (p < 0.05) and 11% and the content of reduced glutathione in the blood by 56% (p < 0.05) and 36% (p < 0.05), respectively, on the 3rd and 7th days of the experiment.

• Authors: S M Nikolaev, A V Fedorov, A A Toropova, Ia G Razuvaeva, Z G Sambueva, P B Lubsandorzhieva
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 77 Issue 9 Pg. 18-22 ( 2014) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 25365865 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Plant Extracts
• Protective Agents
• Malondialdehyde
• Galactosamine
• Cholesterol
• Catalase
• Aspartate Aminotransferases
• Alanine Transaminase
• Alkaline Phosphatase
• Bilirubin

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Animals
• Antioxidants (chemistry, pharmacology)
• Aspartate Aminotransferases (blood)
• Bilirubin (blood)
• Catalase (metabolism)
• Chemical and Drug Induced Liver Injury (drug therapy, metabolism, pathology)
• Cholestasis (chemically induced, drug therapy, metabolism, pathology)
• Cholesterol (blood)
• Female
• Galactosamine
• Lipid Peroxidation (drug effects)
• Liver (drug effects, metabolism, pathology)
• Male
• Malondialdehyde (antagonists & inhibitors, metabolism)
• Papaveraceae (chemistry)
• Plant Extracts (chemistry, pharmacology)
• Protective Agents (chemistry, pharmacology)
• Rats
• Rats, Wistar