Hollow mesoporous organosilica nanoparticles: a generic intelligent framework-hybridization approach for biomedicine.

Abstract

Chemical construction of molecularly organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.

• Authors: Yu Chen, Qingshuo Meng, Meiying Wu, Shige Wang, Pengfei Xu, Hangrong Chen, Yaping Li, Lingxia Zhang, Lianzhou Wang, Jianlin Shi
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 136 Issue 46 Pg. 16326-34 (Nov 19 2014) ISSN: 1520-5126 [Electronic] United States
• PMID: 25343459 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Disulfides
• Drug Carriers
• Organosilicon Compounds
• Doxorubicin

Topics

• Animals
• Disulfides (chemistry)
• Doxorubicin (chemistry, pharmacology)
• Drug Carriers (chemistry)
• Drug Liberation
• Female
• Humans
• MCF-7 Cells
• Mice
• Models, Molecular
• Molecular Conformation
• Nanoparticles (chemistry)
• Organosilicon Compounds (chemistry)
• Porosity
• Ultrasonics
• Xenograft Model Antitumor Assays