Serum C-19 steroid sulphates in females with clinical hyperandrogenism.

Abstract

Serum sulphates of 5-androstene-3 beta, 17 beta-diol (5-ADIOL-S), 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-DIOL-S) and dehydroepiandrosterone (DHEA-S), as well as unconjugated androstenedione (AD), testosterone (T) and 17 alpha-hydroxyprogesterone (17OHP), sex hormone binding globulin (SHBG) and the free androgen index (FAI) were measured by specific radioimmunoassay in girls with premature adrenarche (n = 9-16), and in hirsute women with (1) late onset 21 hydroxylase deficiency (n = 14), (2) polycystic ovarian disease (n = 28) and (3) idiopathic hirsutism (n = 74). Levels were also determined in females with androgenic alopecia (n = 35-45), in normal prepubertal girls (n = 9-14) and in normal adult women (n = 50-73). Mean serum concentrations of 5-ADIOL-S, 3 alpha-DIOL-S, DHEA-S, AD, T, and FAI were elevated and SHBG depressed, in all patient groups compared with controls, except for DHEA-S and T in patients with alopecia. We conclude that in addition to DHEA-S, 5-ADIOL-S may have a role as a pro-hormone in the synthesis of more potent androgens (T, DHT) in peripheral tissues such as skin; in addition, 3 alpha-DIOL-S may be a marker of peripheral androgen metabolism.

• Authors: J Montalo, J W Funder, A B Yong, A Callan, H E Davies, J F Connelly
• Journal: Journal of steroid biochemistry (J Steroid Biochem) Vol. 34 Issue 1-6 Pg. 531-4 ( 1989) ISSN: 0022-4731 [Print] England
• PMID: 2533951 (Publication Type: Journal Article)

Chemical References

• Androgens
• Sex Hormone-Binding Globulin
• Sulfuric Acids
• Dehydroepiandrosterone
• Dehydroepiandrosterone Sulfate

Topics

• Adolescent
• Adult
• Androgens (blood)
• Child
• Child, Preschool
• Dehydroepiandrosterone (analogs & derivatives, blood)
• Dehydroepiandrosterone Sulfate
• Female
• Hirsutism (blood)
• Humans
• Menarche
• Puberty, Precocious (blood)
• Radioimmunoassay
• Sex Hormone-Binding Globulin (analysis)
• Sulfuric Acids (blood)