Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.

Abstract

BACKGROUND:

It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk.

MATERIALS AND METHODS:

We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status.

RESULTS:

Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively).

CONCLUSIONS:

These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.

• Authors: Machiko Minatoya, Goro Kutomi, Hiroaki Shima, Sumiyo Asakura, Seiko Otokozawa, Hirofumi Ohnishi, Hiroshi Akasaka, Tetsuji Miura, Mitsuru Mori, Koichi Hirata
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 19 Pg. 8325-30 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25339024 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adiponectin
• Biomarkers, Tumor

Topics

• Adiponectin (blood)
• Adult
• Biomarkers, Tumor (blood)
• Body Mass Index
• Breast Neoplasms (blood, diagnosis, etiology)
• Case-Control Studies
• Female
• Follow-Up Studies
• Humans
• Neoplasm Staging
• Obesity (complications, physiopathology)
• Odds Ratio
• Postmenopause
• Premenopause
• Prognosis
• Risk Factors