Abstract | BACKGROUND: METHODS: Altogether, 108 patients with HCTC (26 male, 82 female; median age 62 years; range 19-87 years) treated at our Institute from 1972 to 2011 were included in the present retrospective study. Data on age, clinical and histopathological factors, tumor stage, recurrence, disease-free and disease-specific survival were collected. Univariate analysis was used to identify factors associated with disease-specific survival. Cox's multivariate regression model was used to identify independent prognostic factors for disease-specific survival. RESULTS: The follow-up period was 1 to 337 (median 105) months. Of 108 patients, 12 (11%) had distant and 8 (7%) had locoregional metastases before primary treatment. Recurrence was diagnosed in 26 cases (24%): locoregional, distant, and both locoregional and distant in 12, 11, and 3 cases, respectively. The 5-year, 10-year, and 20-year disease-specific survival were 96%, 88%, and 67%, respectively. Independent prognostic factors for disease-specific survival were: age of patients at diagnosis, distant metastases and residual tumor after surgery. CONCLUSION: Long disease-specific survival was found in patients with HCTC younger than 45 years of age without distant metastases and without residual tumor after surgery.
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Authors | Rok Petric, Barbara Gazic, Nikola Besic |
Journal | BMC cancer
(BMC Cancer)
Vol. 14
Pg. 777
(Oct 23 2014)
ISSN: 1471-2407 [Electronic] England |
PMID | 25338674
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adenoma, Oxyphilic
- Adult
- Aged
- Aged, 80 and over
- Combined Modality Therapy
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Prognosis
- Retrospective Studies
- Survival Analysis
- Thyroid Neoplasms
(epidemiology, mortality, pathology, therapy)
- Young Adult
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