Abstract | PURPOSE: METHODS: In all, 4,046 patients with HER2-positive operable breast cancer were enrolled to receive doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in both trials. The required number of events for the definitive statistical analysis for OS (710 events) was reached in September 2012. Updated analyses of overall DFS and related subgroups were also performed. RESULTS: Median time on study was 8.4 years. Adding trastuzumab to chemotherapy led to a 37% relative improvement in OS (hazard ratio [HR], 0.63; 95% CI, 0.54 to 0.73; P < .001) and an increase in 10-year OS rate from 75.2% to 84%. These results were accompanied by an improvement in DFS of 40% (HR, 0.60; 95% CI, 0.53 to 0.68; P < .001) and increase in 10-year DFS rate from 62.2% to 73.7%. All patient subgroups benefited from addition of this targeted anti-HER2 agent. CONCLUSION:
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Authors | Edith A Perez, Edward H Romond, Vera J Suman, Jong-Hyeon Jeong, George Sledge, Charles E Geyer Jr, Silvana Martino, Priya Rastogi, Julie Gralow, Sandra M Swain, Eric P Winer, Gerardo Colon-Otero, Nancy E Davidson, Eleftherios Mamounas, Jo Anne Zujewski, Norman Wolmark |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 32
Issue 33
Pg. 3744-52
(Nov 20 2014)
ISSN: 1527-7755 [Electronic] United States |
PMID | 25332249
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 by American Society of Clinical Oncology. |
Chemical References |
- Antibodies, Monoclonal, Humanized
- ERBB2 protein, human
- Receptor, ErbB-2
- Trastuzumab
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal, Humanized
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(chemistry, drug therapy, mortality)
- Chemotherapy, Adjuvant
- Disease-Free Survival
- Female
- Humans
- Middle Aged
- Receptor, ErbB-2
(analysis)
- Trastuzumab
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