Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome.

Abstract

BACKGROUND & AIMS:

Few studies have examined the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome (PCOS). This study was conducted to determine the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations among overweight and obese vitamin D deficient women with PCOS.

METHODS:

This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obese vitamin D deficient women diagnosed with PCOS. Participants were randomly assigned into four groups to receive: 1) 1000 mg/d calcium + vitamin D placebo (n = 26); 2) 50,000 IU/wk vitamin D + calcium placebo (n = 26); 3) 1000 mg calcium/d + 50,000 IU/wk vitamin D (n = 26) and 4) calcium placebo + vitamin D placebo (n = 26) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to measure glucose metabolism and lipid concentrations.

RESULTS:

Calcium-vitamin D co-supplementation resulted in higher levels of serum calcium (P = 0.002) and vitamin D (P < 0.001) compared with other groups. Co-supplementation, compared with other groups, led to decreased serum insulin levels (P = 0.03), homeostasis model of assessment-insulin resistance (HOMA-IR) score (P = 0.04) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (P = 0.001). Furthermore, a significant decrease in serum triglycerides (P = 0.02) and VLDL-cholesterol levels (P = 0.02) was seen following the administration of calcium plus vitamin D supplements compared with the other groups. Co-supplementation with calcium and vitamin D had no significant effects on FPG, total-, LDL-, HDL-, and non-HDL-cholesterol levels.

CONCLUSIONS:

In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles. Clinical registration numberwww.irct.ir: IRCT201309275623N10.

• Authors: Zatollah Asemi, Fatemeh Foroozanfard, Teibeh Hashemi, Fereshteh Bahmani, Mehri Jamilian, Ahmad Esmaillzadeh
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 34 Issue 4 Pg. 586-92 (Aug 2015) ISSN: 1532-1983 [Electronic] England
• PMID: 25300649 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Chemical References

• Blood Glucose
• Calcium, Dietary
• Cholesterol, HDL
• Cholesterol, LDL
• Insulin
• Triglycerides
• Vitamin D

Topics

• Adolescent
• Adult
• Blood Glucose (metabolism)
• Body Mass Index
• Calcium, Dietary (administration & dosage)
• Carbohydrate Metabolism (drug effects)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Dietary Supplements
• Double-Blind Method
• Energy Intake
• Fasting
• Female
• Humans
• Insulin (blood)
• Insulin Resistance
• Lipid Metabolism (drug effects)
• Obesity (blood, drug therapy)
• Overweight (blood, drug therapy)
• Polycystic Ovary Syndrome (blood, drug therapy)
• Triglycerides (blood)
• Vitamin D (administration & dosage)
• Vitamin D Deficiency (blood, drug therapy)
• Waist Circumference
• Young Adult