Abstract | PURPOSE: METHODS: One hundred eyes of 100 cases, including 51 mCNV eyes, 14 highly myopic eyes without choroidal neovascularization, and 35 normal subjects, were studied. The intraocular levels of choroidal neovascularization-related cytokines, like vascular endothelial growth factor, MCP-1, IL-8, IL-10, and IL-23, were determined. RESULTS: The levels of vascular endothelial growth factor and IL-8 were significantly higher in eyes with mCNV than in high myopia eyes without mCNV with significant odds ratio of 2.00 and 2.25 per quartile, respectively (P < 0.05). When myopic lesions of patients with mCNV were classified into 3 categories based on the severity, IL-8 and MCP-1 were significantly elevated depending on the presence of maculopathy (P < 0.05). Vascular endothelial growth factor was significantly elevated in eyes of Category 2. An advancement of the maculopathy category was significantly associated with the need for multiple treatment of intravitreal bevacizumab (P < 0.05). In 12 eyes that required multiple intravitreal bevacizumab, the MCP-1 level was significantly elevated. CONCLUSION:
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Authors | Yukimi Yamamoto, Dai Miyazaki, Shin-Ichi Sasaki, Ken-Ichiro Miyake, Shuzo Kaneda, Yoshifumi Ikeda, Takashi Baba, Atsushi Yamasaki, Yumiko Noguchi, Yoshitsugu Inoue |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 35
Issue 2
Pg. 344-50
(Feb 2015)
ISSN: 1539-2864 [Electronic] United States |
PMID | 25289657
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- Cytokines
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Bevacizumab
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Topics |
- Aged
- Angiogenesis Inhibitors
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Aqueous Humor
(metabolism)
- Bevacizumab
- Choroidal Neovascularization
(diagnosis, drug therapy, metabolism)
- Cytokines
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Intravitreal Injections
- Male
- Middle Aged
- Myopia, Degenerative
(diagnosis, metabolism)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
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