Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?

Abstract

Ezrin, radixin and moesin, which are strongly expressed in the Schwann cell microvilli, are putative targets for autoantibodies in acute or chronic inflammatory demyelinating polyneuropathy (AIDP or CIDP). An association between anti-moesin IgG antibodies and cytomegalovirus-related AIDP has been postulated. None of 41 AIDP patients, including 8 cytomegalovirus-related AIDP patients, and 23 CIDP had IgG or IgM antibodies to ezrin, radixin and moesin; whereas, one patient with cytomegalovirus-related AIDP had anti-ezrin IgM antibodies. Ezrin, radixin and moesin are unlikely targets for autoantibodies in AIDP and CIDP, and the association of anti-moesin antibodies with cytomegalovirus-related AIDP was not confirmed.

• Authors: Kazuki Miyaji, Nortina Shahrizaila, Thirugnanam Umapathi, Yee-Cheun Chan, Koichi Hirata, Nobuhiro Yuki
• Journal: Human immunology (Hum Immunol) Vol. 75 Issue 11 Pg. 1089-91 (Nov 2014) ISSN: 1879-1166 [Electronic] United States
• PMID: 25286001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Chemical References

• Autoantibodies
• Cytoskeletal Proteins
• Immunoglobulin G
• Immunoglobulin M
• Membrane Proteins
• Microfilament Proteins
• ezrin
• moesin
• radixin

Topics

• Autoantibodies (blood)
• Cytoskeletal Proteins (genetics, metabolism)
• Female
• Gene Expression
• Guillain-Barre Syndrome (blood, genetics, immunology, pathology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Male
• Membrane Proteins (genetics, metabolism)
• Microfilament Proteins (genetics, metabolism)
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood, genetics, immunology, pathology)