Abstract | BACKGROUND: METHODS: Fifty-eight patients (67% male, mean age: 36.5 years) with HIV/HCV- co-infection were included in the study. Hepatic venous pressure gradient (HVPG) was measured in forty-three patients. The fibrosis stage was determined using FIB4 -Score. ECM degraded products in peripheral blood were measured using specific ELISAs (C4M, MMP-2/9 degraded type IV collagen; C5M, MMP-2/9 degraded type V collagen; PRO-C3, MMP degraded n-terminal propeptide of type III collagen). RESULTS: As expected, HVPG showed strong and significant correlations with FIB4-index (rs = 0.628; p = 7*10-7). Interestingly, PRO-C3 significantly correlated with HVPG (rs = 0.354; p = 0.02), alanine aminotransferase (rs = 0.30; p = 0.038), as well as with FIB4-index (rs = 0.3230; p = 0.035). C4M and C5M levels were higher in patients with portal hypertension (HVPG>5 mmHg). CONCLUSION:
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Authors | Christian Jansen, Diana J Leeming, Mattias Mandorfer, Inger Byrjalsen, Robert Schierwagen, Philipp Schwabl, Morten A Karsdal, Evrim Anadol, Christian P Strassburg, Jürgen Rockstroh, Markus Peck-Radosavljevic, Søren Møller, Flemming Bendtsen, Aleksander Krag, Thomas Reiberger, Jonel Trebicka |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 9
Pg. e108544
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25265505
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Complement C3
- Complement C4
- Complement C5
- Alanine Transaminase
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Coinfection
(blood, immunology)
- Complement C3
(immunology)
- Complement C4
(immunology)
- Complement C5
(immunology)
- Extracellular Matrix
(pathology)
- Female
- HIV Infections
(blood, immunology)
- Hepatitis C, Chronic
(blood, immunology)
- Humans
- Hypertension, Portal
- Liver
(injuries)
- Liver Cirrhosis
(blood, immunology)
- Male
- Middle Aged
- Portal Pressure
- Retrospective Studies
- Young Adult
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