Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta-analysis.

Abstract

We aimed to assess the effects of childhood obesity prevention programmes on blood lipids in high-income countries. We searched MEDLINE®, Embase, PsychInfo, CINAHL®, clinicaltrials.gov, and the Cochrane Library up to 22 April 2013 for relevant randomized controlled trials, quasi-experimental studies and natural experiments published in English. Studies were included if they implemented diet and/or physical activity intervention(s) with ≥1 year follow-up (or ≥6 months for school-based intervention studies) in 2-18-year-olds, and were excluded if they targeted only overweight/obese children, or those with a pre-existing medical condition. Seventeen studies were finally included. For total cholesterol, the pooled intervention effect was -0.97 mg dL(-1) [95% confidence interval (CI): -3.26, 1.32; P = 0.408]; for low-density lipoprotein cholesterol (LDL-C), -6.06 mg dL(-1) (95% CI: -11.09, -1.02; P = 0.018); for high-density lipoprotein cholesterol (HDL-C), 1.87 mg dL(-1) (95% CI: 0.39, 3.34; P = 0.013); and for triglycerides, -1.95 mg dL(-1) (95% CI: -4.94, 1.04; P = 0.202). Most interventions (70%) showed similar significant or no effects on adiposity- and lipids outcomes: 15% interventions improved both adiposity- and lipids outcomes; 55% had no significant effects on either. Childhood obesity prevention programmes had a significant desirable effect on LDL-C and HDL-C. Two-thirds of interventions showed similar significant or no effects in adiposity- and lipids outcomes. Assessing lipids outcomes provide additional useful information on obesity prevention programme benefits.

• Authors: L Cai, Y Wu, L J Cheskin, R F Wilson, Y Wang
• Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity (Obes Rev) Vol. 15 Issue 12 Pg. 933-44 (Dec 2014) ISSN: 1467-789X [Electronic] England
• PMID: 25263653 (Publication Type: Journal Article, Meta-Analysis, Research Support, U.S. Gov't, P.H.S., Review, Systematic Review)
• Copyright: © 2014 World Obesity.

Chemical References

• Lipids

Topics

• Adiposity
• Adolescent
• Child
• Child, Preschool
• Diet
• Exercise
• Humans
• Lipids (blood)
• MEDLINE
• Pediatric Obesity (prevention & control)
• Randomized Controlled Trials as Topic
• School Health Services
• Socioeconomic Factors
• Treatment Outcome