Abstract | INTRODUCTION: METHODS: RESULTS:
URB597 decreased leukocyte rolling and adhesion, as well as inflammation-induced hyperaemia. However, these effects were only apparent at low doses and the effects of URB597 were absent at higher doses. In addition to the anti-inflammatory effects of URB597, fatty acid amide hydrolase (FAAH) inhibition improved both hindlimb weight bearing and von Frey hair withdrawal thresholds. The anti-inflammatory effects of URB597 on leukocyte rolling and vascular perfusion were blocked by both CB1 and CB2 antagonism, while the effect on leukocyte adherence was independent of cannabinoid receptor activation. The analgesic effects of URB597 were CB1 mediated. CONCLUSIONS: These results suggest that the endocannabinoid system of the joint can be harnessed to decrease acute inflammatory reactions and the concomitant pain associated with these episodes.
|
Authors | Eugene Krustev, Allison Reid, Jason J McDougall |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 16
Issue 5
Pg. 437
(Sep 27 2014)
ISSN: 1478-6362 [Electronic] England |
PMID | 25260980
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Benzamides
- Carbamates
- Endocannabinoids
- Indoles
- Piperidines
- Pyrazoles
- Receptor, Cannabinoid, CB1
- Receptor, Cannabinoid, CB2
- cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester
- Kaolin
- AM 251
- Carrageenan
- Amidohydrolases
- fatty-acid amide hydrolase
- iodopravadoline
|
Topics |
- Acute Disease
- Amidohydrolases
(antagonists & inhibitors, metabolism)
- Animals
- Arthralgia
(metabolism, prevention & control)
- Benzamides
(pharmacology)
- Carbamates
(pharmacology)
- Carrageenan
- Endocannabinoids
(metabolism)
- Hindlimb
(drug effects, physiopathology)
- Hyperalgesia
(metabolism, physiopathology, prevention & control)
- Indoles
(pharmacology)
- Inflammation
(chemically induced, metabolism, prevention & control)
- Kaolin
- Knee Joint
(drug effects, metabolism, physiopathology)
- Male
- Mice, Inbred C57BL
- Piperidines
(pharmacology)
- Pyrazoles
(pharmacology)
- Receptor, Cannabinoid, CB1
(antagonists & inhibitors, metabolism)
- Receptor, Cannabinoid, CB2
(antagonists & inhibitors, metabolism)
- Synovitis
(metabolism, prevention & control)
- Weight-Bearing
|