Abstract | BACKGROUND: OBJECTIVE: The objective of the study was to evaluate the usefulness of intra-arterial chemotherapy including ICA infusion for treating advanced paranasal sinus carcinomas, which have invaded the skull base. METHODS: Forty-six patients with advanced paranasal sinus carcinomas supplied by ICA were treated by intra-arterial chemotherapy using CDDP and sodium thiosulphate (STS) as a neutraliser of CDDP toxicity. After evaluating CT angiography, 150 mg m(-2) of CDDP was superselectively administered weekly to each feeding artery including ICA four times. RESULTS: The 10-year overall survival rate and progression-free survival rate were 70.7 and 60.2%, respectively. Compared with control group without infusing ICA, recurrences at anterior skullbase or anterior ethomoid sinus were significantly diminished. Of 32 patients in which the orbital apex had been invaded, 29 patients were treated with successful preservation of orbital contents. The CT angiography could efficiently determine all feeding arteries supplying the cancers. Consequently, chemotherapy could be administered on schedule, and side effects were minimal and acceptable. CONCLUSIONS: This new method has promising applications in the treatment of advanced paranasal sinus carcinomas involving the skull base.
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Authors | J Yokoyama, S Ohba, M Fujimaki, T Anzai, M Kojima, K Ikeda, M Suzuki, H Yoshimoto, K Inoue |
Journal | British journal of cancer
(Br J Cancer)
Vol. 111
Issue 12
Pg. 2229-34
(Dec 09 2014)
ISSN: 1532-1827 [Electronic] England |
PMID | 25255100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Cisplatin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage)
- Carotid Artery, Internal
- Cisplatin
(administration & dosage)
- Disease-Free Survival
- Female
- Humans
- Infusions, Intra-Arterial
- Male
- Middle Aged
- Paranasal Sinus Neoplasms
(drug therapy)
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