Plasma miR-454-3p as a potential prognostic indicator in human glioma.
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| Abstract |
microRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21-25 nucleotides in length. Recently, some researchers have demonstrated that plasma miRNAs are sensitive and specific biomarkers of various cancers. Using quantitative real-time PCR, the expression levels of miR-454-3p were compared between pre-operative plasmas from 70 glioma patients and 70 healthy controls, and between these pre-operative and post-operative plasmas. Kaplan-Meier analysis was used to evaluate the association of miR-454-3p with prognosis of glioma patients. The expression levels of miR-454-3p in plasma in glioma patients were significantly higher than that from healthy controls. The expression levels of miR-454-3p were higher in high grade gliomas than in low grade gliomas. The AUC of the expression of miR-454-3p in plasma for glioma diagnosis was 0.9063. The expression levels of miR-454-3p in the post-operative plasmas were significantly downregulated when compared to the pre-operative plasmas. Moreover, the prognosis of glioma with high miR-454-3p expression was significantly worse compared with that of glioma with low miR-454-3p expression. Our results suggested that plasma miR-454-3p could be a novel potential diagnostic biomarker for glioma.
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| Authors | Naiyuan Shao, Lei Wang, Lian Xue, Rong Wang, Qing Lan |
| Journal | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 36 Issue 2 Pg. 309-13 (Feb 2015) ISSN: 1590-3478 [Electronic] Italy |
| PMID | 25190548 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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