Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients undergoing surgery for gastric cancer.

Abstract

OBJECTIVE:

To investigate the clinical utility of the Combination of Platelet count and Neutrophil to Lymphocyte Ratio (COP-NLR) for predicting the postoperative survival of patients undergoing surgery for gastric cancer (GC).

METHODS:

The COP-NLR was calculated on the basis of data obtained on the day of admission as follows: patients with both an elevated platelet count (>300 × 10(3) /µl) and an elevated NLR (>3) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. Five hundred forty-four patients for whom data were sufficient to allow analysis of the relationship between clinicolaboratory characteristics and postoperative survival were enrolled.

RESULTS:

Multivariate analysis using the 12 clinical characteristics selected by univariate analyses revealed that the COP-NLR was associated with OS (hazard ratio, 1.781; 95% C.I., 1.094-2.899; P = 0.020) along with age, tumor type, lymph node metastasis and albumin level. Kaplan-Meier analysis and log rank test demonstrated significant differences in both OS and cancer-specific survival among patients with COP-NLR 0, 1, and 2 (P < 0.001).

CONCLUSION:

The COP-NLR is able to predict postoperative survival of patients with GC and classify such patients into three independent groups before surgery.

• Authors: Mitsuru Ishizuka, Yusuke Oyama, Akihito Abe, Keiichi Kubota
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 110 Issue 8 Pg. 935-41 (Dec 2014) ISSN: 1096-9098 [Electronic] United States
• PMID: 25146385 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Topics

• Aged
• Female
• Humans
• Lymphocytes
• Male
• Middle Aged
• Multivariate Analysis
• Neutrophils
• Platelet Count
• Stomach Neoplasms (blood, mortality, pathology, surgery)