No correlation between TIMP2 -418 G>C polymorphism and increased risk of cancer: evidence from a meta-analysis.

Abstract

AIM:

Tissue inhibitor of metalloproteinase (TIMP2) is involved in the regulation of matrix metalloproteinase 2 (MMP2) and shown to implicate in cancer development and progression. The results from the published studies based on the association between TIMP2 -418 G>C polymorphism and cancer risk are inconsistent. In this meta-analysis, we aimed to evaluate the potential association between TIMP2 -418 G>C polymorphism and cancer risk.

METHODOLOGY:

We searched PubMed (Medline) and EMBASE web databases to cover all studies based on relationship of TIMP2 -418 G>C polymorphism and risk of cancer until October 2013. The meta-analysis was performed for selected case-control studies and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all genetic models.

RESULTS:

A total of 2225 cancer cases and 2532 controls were included from ten eligible case-control studies. Results from overall pooled analysis suggested no evidence of significant risk between TIMP2 -418 G>C polymorphism and cancer risk in any of the genetic models, such as, allele (C vs. G: OR = 1.293, 95% CI = 0.882 to 1.894, p = 0.188), homozygous (CC vs. GG: OR = 0.940, 95% CI = 0.434 to 2.039, p = 0.876), heterozygous (GC vs. GG: OR = 1.397, 95% CI = 0.888 to 2.198, p = 0.148), dominant (CC+GC vs. GG: OR = 1.387, 95% CI = 0.880 to 2.187, p = 0.159) and recessive (CC vs. GG+GC: OR = 0.901, 95% CI = 0.442 to 1.838, p = 0.774) models. No evidence of publication bias was detected during the analysis.

CONCLUSIONS:

The present meta-analysis suggests that the TIMP2 -418 G>C polymorphism may not be involved in predisposing risk factor for cancer in overall population. However, future larger studies with group of populations are needed to analyze the possible correlation.

• Authors: Raju K Mandal, Naseem Akhter, Shafiul Haque, Aditya K Panda, Rama D Mittal, Mohammed A A Alqumber
• Journal: PloS one (PLoS One) Vol. 9 Issue 8 Pg. e88184 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 25136829 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• TIMP2 protein, human
• Tissue Inhibitor of Metalloproteinase-2

Topics

• Alleles
• Case-Control Studies
• Genetic Predisposition to Disease (genetics)
• Heterozygote
• Homozygote
• Humans
• Neoplasms (genetics)
• Polymorphism, Genetic (genetics)
• Risk
• Risk Factors
• Tissue Inhibitor of Metalloproteinase-2 (genetics)