Cognitive judgment bias in the psychostimulant-induced model of mania in rats.

Abstract

RATIONALE:

Animal models of mania lack genuine cognitive parameters. The present gold standard of mania models, amphetamine-induced hyperlocomotion, is rather unspecific and does not necessarily target its cardinal symptoms. Therefore, alternative behavioral markers that are sensitive to stimulants are required.

OBJECTIVES:

In the present study, by combining the psychostimulant-induced model of mania in rodents with the recently developed ambiguous-cue interpretation (ACI) tests, we investigated the effects of chronic administration of D-amphetamine and cocaine on the cognitive judgment bias of rats.

METHODS:

To accomplish this goal, in two separate experiments, previously trained animals received chronic, daily injections of either D-amphetamine (2 mg/kg) or cocaine (10 mg/kg) for 2 weeks and were subsequently tested with the ACI procedure.

RESULTS:

Chronic treatment with both psychostimulants did not make rats more "optimistic."

CONCLUSIONS:

The results are discussed in terms of behavioral and pharmacological actions of the tested compounds and their implications for modeling mania in animals.

• Authors: Rafal Rygula, Ewa Szczech, Jakub Kregiel, Joanna Golebiowska, Jakub Kubik, Piotr Popik
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 232 Issue 3 Pg. 651-60 (Feb 2015) ISSN: 1432-2072 [Electronic] Germany
• PMID: 25116482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine Uptake Inhibitors
• Cocaine
• Dextroamphetamine

Topics

• Animals
• Behavior, Animal (drug effects)
• Bipolar Disorder (chemically induced, physiopathology)
• Cocaine (administration & dosage, pharmacology)
• Dextroamphetamine (administration & dosage, pharmacology)
• Disease Models, Animal
• Dopamine Uptake Inhibitors (administration & dosage, pharmacology)
• Judgment (drug effects)
• Male
• Rats
• Rats, Sprague-Dawley