Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project.

Abstract

OBJECTIVES:

To examine the associations between serum 25-hydroxyvitamin D (25OHD) levels and the active vitamin D metabolite, 1,25-hydroxyvitamin D (1,25OHD), with type 2 diabetes mellitus (DM) in community-living men aged 70 and older.

DESIGN:

Cross-sectional.

SETTING:

A population-based, cross-sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project (CHAMP), a large epidemiological study conducted in Sydney between January 2005 and May 2007.

PARTICIPANTS:

Community dwelling men aged 70 and older taking part in CHAMP (N = 1,659).

MEASUREMENTS:

Serum 25OHD and 1,25OHD levels, presence of DM, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium.

RESULTS:

The prevalence of DM was 20.0%. There was a significant association between low 25OHD and 1,25OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications.

CONCLUSION:

25OHD and 1,25OHD levels were associated with DM. The independent association between serum 25OHD and 1,25OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways.

• Authors: Vasant Hirani, Robert G Cumming, David G Le Couteur, Vasikaran Naganathan, Fiona Blyth, David J Handelsman, Louise M Waite, Markus J Seibel
• Journal: Journal of the American Geriatrics Society (J Am Geriatr Soc) Vol. 62 Issue 9 Pg. 1741-7 (Sep 2014) ISSN: 1532-5415 [Electronic] United States
• PMID: 25112415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

Chemical References

• Vitamin D
• 1,25-dihydroxyvitamin D
• 25-hydroxyvitamin D

Topics

• Aged
• Aged, 80 and over
• Australia (epidemiology)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, epidemiology)
• Humans
• Logistic Models
• Male
• Vitamin D (analogs & derivatives, blood)