Trend in vancomycin susceptibility and correlation with molecular characteristics of methicillin-resistant Staphylococcus aureus causing invasive infections in Taiwan: results from the Tigecycline in vitro Surveillance in Taiwan (TIST) study, 2006-2010.
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| Abstract |
This study was intended to investigate the trend in vancomycin susceptibility and correlation with molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) causing invasive infections. A total of 670 MRSA isolates were collected from patients with invasive infections as part of bacterial collection in the Tigecycline in vitro Surveillance in Taiwan (TIST) from 2006 to 2010. MICs of the isolates to vancomycin were determined using the agar dilution method. Characteristics of staphylococcal cassette chromosome mec (SCCmec), mec-associated hypervariable region (dru), and accessory gene regulator (agr) of the isolates were identified by polymerase chain reaction methods. MRSA isolates with SCCmec types I, II, and III were molecularly defined as hospital-associated MRSA (HA-MRSA), and those with SCCmec types IV, V, and VT were assigned as community-associated MRSA (CA-MRSA). All but 1 MRSA isolates exhibited vancomycin MICs ≤1 mg/L. A declining trend in vancomycin MICs among MRSA isolates was noted, which was associated with the decline in proportion of HA-MRSA. The percentage of CA-MRSA increased from 25.6% in 2006 to 46.0% in 2010. An increase in the geometric mean of vancomycin MICs was found in MRSA with particular molecular types such as SCCmec types II and III, agr groups I and II, and dru10-14. A significant correlation among particular molecular types was found, including SCCmecII-agr group II-dru4, SCCmecIII-agr group I-dru11-14, SCCmecIV-agr group II-dru9, and SCCmecVT-agr group I-dru9 and dru11. There was no vancomycin creep among MRSA isolates, and the declining trend of vancomycin MIC against MRSA was attributed to the increasing prevalence of CA-MRSA over time.
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| Authors | Shin-Ming Tsao, Wei-Yao Wang, Wen-Chien Ko, Cheng-Hua Huang, Chin-Te Lu, Yin-Ching Chuang, Chia-Ying Liu, Chun-Hsing Liao, Yao-Shen Chen, Yung-Ching Liu, Wei-Yu Chen, Tsrang-Neng Jang, Hsiu-Chen Lin, Chih-Ming Chen, Zhi-Yuan Shi, Sung-Ching Pan, Jia-Ling Yang, Hsiang-Chi Kung, Chun-Eng Liu, Yu-Jen Cheng, Jien-Wei Liu, Wu Sun, Lih-Shinn Wang, Kwok-Woon Yu, Ping-Cherng Chiang, Ming-Hsun Lee, Chun-Ming Lee, Gwo-Jong Hsu, Yen-Hsu Chen, Po-Liang Lu, Chang-Yao Tsao Thomas, Po-Ren Hsueh |
| Journal | Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 80 Issue 2 Pg. 162-7 (Oct 2014) ISSN: 1879-0070 [Electronic] United States |
| PMID | 25053202 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
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