Acquired Von Willebrand syndrome secondary to mitral and aortic regurgitation.

Abstract	The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement.
Authors	Siu-Hin Wan, Jackson J Liang, Rakhee Vaidya, Joseph L Blackshear, Dong Chen
Journal	The Canadian journal of cardiology (Can J Cardiol) Vol. 30 Issue 9 Pg. 1108.e9-1108.e10 (Sep 2014) ISSN: 1916-7075 [Electronic] England
PMID	24994586 (Publication Type: Case Reports, Journal Article)
Copyright	Copyright © 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Topics	Aortic Valve Insufficiency (complications, etiology) Endocarditis (complications) Humans Male Middle Aged Mitral Valve Insufficiency (complications) von Willebrand Diseases (etiology)

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