[Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents].

Abstract

OBJECTIVE:

To study the relationship between rs2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents.

METHODS:

In our study, 2 030 children and adolescents aged from 7 to 18 years participated. Anthropometric measurements, including height and weight, were performed. Their serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to detect rs2228314 genotypes.

RESULTS:

The GC/CC genotypes of rs2228314 polymorphisms had lower HDL-C levels than GG genotype [(0.10 ± 0.35) mmol/L vs. (0.14 ± 0.36) mmol/L, P=0.020]. The rs2228314 polymorphism was associated with the abnormal HDL-C level under the dominant model after adjustment for study samples, sex and age (OR=1.400, 95% CI: 1.027-1.907, P=0.033). The rs2228314 polymorphism was not associated with obesity under the dominant model after adjustment for study samples, sex, age and HDL-C level (OR=1.178,95% CI: 0.971-1.430, P=0.096).

CONCLUSION:

The GC/CC genotype carriers of SREBP2 rs2228314 polymorphism have higher risk of abnormal HDL-C level than the individuals with GG genotype among children and adolescents.

• Authors: Fang-hong Liu, Jjie-yun Song, Jun Ma, Xiao-rui Shang, Xiang-rui Meng, Hai-jun Wang
• Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 46 Issue 3 Pg. 355-9 (Jun 18 2014) ISSN: 1671-167X [Print] China
• PMID: 24943010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Lipids
• SREBF2 protein, human
• Sterol Regulatory Element Binding Protein 2
• Triglycerides

Topics

• Adolescent
• Child
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Genotype
• Humans
• Lipids (blood)
• Obesity (blood, genetics)
• Polymorphism, Genetic
• Sterol Regulatory Element Binding Protein 2 (genetics)
• Triglycerides (blood)