Concurrent subcutaneous candidal abscesses and pulmonary cryptococcosis in a patient with diabetes mellitus and a history of corticosteroid therapy.

Abstract

A 50-year-old man with a history of long-term corticosteroid treatment following adrenalectomy for Cushing's syndrome and uncontrolled diabetes mellitus was admitted for an examination of an abnormal thoracic shadow. Cryptococcal serum antigens were positive, and the histopathology of a lung biopsy showed encapsulated yeast resembling Cryptococcus neoformans. On admission, the serum β-D-glucan level was approximately twice the cutoff value, several nodules were observed on both legs and magnetic resonance imaging revealed subcutaneous abscesses. Candida albicans was identified from needle aspirates, and the patient was successfully treated with fluconazole and flucytosine. We herein report the first case of concurrent C. albicans skin abscesses and pulmonary cryptococcosis.

• Authors: Hiroshi Kakeya, Koichi Izumikawa, Koichi Yamada, Yusuke Narita, Tomoya Nishino, Yoko Obata, Takahiro Takazono, Shintaro Kurihara, Kosuke Kosai, Yoshitomo Morinaga, Shigeki Nakamura, Yoshifumi Imamura, Taiga Miyazaki, Misuzu Tsukamoto, Katsunori Yanagihara, Motoi Takenaka, Takayoshi Tashiro, Shigeru Kohno
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 12 Pg. 1385-90 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 24930663 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glucocorticoids

Topics

• Abscess (diagnosis, etiology)
• Adrenalectomy
• Candida albicans
• Candidiasis, Cutaneous (diagnosis, etiology)
• Cryptococcosis (diagnosis, etiology)
• Cushing Syndrome (complications, therapy)
• Diabetes Mellitus, Type 2 (complications)
• Glucocorticoids (administration & dosage)
• Humans
• Lung Diseases, Fungal (diagnosis, etiology)
• Male
• Middle Aged