Clinical effectiveness of Novolin® 30R versus Lantus® combined with Glucobay® treatment in elderly patients with type 2 diabetes mellitus controlled by oral hypoglycaemic agents: A randomized study.

Abstract

OBJECTIVE:

To compare the treatment effects of Novolin® 30R(a), versus Lantus(®a) combined with acarbose (Glucobay®), in elderly patients with type 2 diabetes mellitus.

METHODS:

Patients (aged > 60 years) with type 2 diabetes mellitus were randomized to receive either Novolin® 30R(a) (initial dose 0.5 IU/kg) or Lantus(®a) (initial dose 0.2 IU/kg) combined with 50 mg acarbose. After a 32-week treatment period, the following parameters were measured: blood glucose control; blood lipid levels; body mass index; proportion of patients achieving a glycosylated haemoglobin (HbA1c) level <7.5%; rate of hypoglycaemic events; change in fasting blood glucose levels from baseline in patients stratified according to their baseline HbA1c level.

RESULTS:

A total of 188 patients were enrolled in the study. After 32 weeks' treatment, compared with baseline levels, there were significant reductions in FBG, 2 h-postprandial blood glucose during an oral glucose tolerance test, HbA1c, total cholesterol, triglycerides and low-density lipoprotein cholesterol values in both groups. Although there were fewer hypoglycaemic events in the Lantus® combined with Glucobay® group compared with the Novolin® 30R group, the difference was not significant.

CONCLUSION:

Novolin® 30R and Lantus® combined with acarbose both had beneficial effects on blood glucose control and blood lipid levels in elderly patients with type 2 diabetes mellitus.

• Authors: Yixuan Sun, Li Shao, Xianping Niu, Yue Liu, Jianli Ge, Hua Jiang, Hua Zhang
• Journal: The Journal of international medical research (J Int Med Res) Vol. 42 Issue 4 Pg. 993-1001 (Aug 2014) ISSN: 1473-2300 [Electronic] England
• PMID: 24925584 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin
• Lipids
• hemoglobin A1c protein, human
• Insulin Glargine
• Acarbose

Topics

• Acarbose (therapeutic use)
• Aged
• Blood Glucose (drug effects)
• Body Mass Index
• Diabetes Mellitus, Type 2 (drug therapy)
• Drug Therapy, Combination
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Insulin Glargine (therapeutic use)
• Lipids (blood)
• Male
• Prospective Studies