Serum CA125 level predicts prognosis in patients with multiple brain metastases from non-small cell lung cancer before and after treatment of whole-brain radiotherapy.

Abstract

This study was to evaluate the effect of serum CA125 level on the prognosis of patients with multiple brain metastases from non-small cell lung cancer before and after treatment of whole-brain radiotherapy. Sixty-six patients with multiple brain metastases from non-small cell lung cancer before and after treatment of radiotherapy were reviewed retrospectively. Radiotherapy was given to the whole brain using opposed 6MV lateral beams with a dose of 30 Gy in 15 fractions in 3 weeks. Elevated CA125 was defined as >35 U/mL. The survival rate was calculated using the Kaplan-Meier method, and the univariate and multivariate analyses were used to identify significant factors associated with prognosis, using a Cox proportional hazards model. During the median (range) follow-up of 1.25 (0.25-2.50) years, 62 patients died from non-small cell lung cancer; the 1-year cancer-specific survival (CSS) rate was 43.08 %. Thirty patients had a high CA125 level before chemoradiotherapy (>35U/mL), and their CSS rate was significantly worse than that in the remaining patients (P = 0.024). Multivariate analysis showed that CA125 level, number of metastases and total tumor volume were independent prognostic indicators for CSS, with a hazard ratio of 1.99, 1.67 and 2.02, respectively. The elevation of CA125 before treatment predicts a poor prognosis in patients with multiple brain metastases from non-small cell lung cancer before and after treatment of whole-brain radiotherapy.

• Authors: Yue-Can Zeng, Rong Wu, Si-Liang Wang, Feng Chi, Rui Xing, Wei-Song Cai, Guo-Liang Fan, Yu-Chen Fan, Wen-Zhao Zhong, Li-Na Wu, Xiao-Dong Chen, Huan-Huan Chen, Yu-Ping Xiao
• Journal: Medical oncology (Northwood, London, England) (Med Oncol) Vol. 31 Issue 7 Pg. 48 (Jul 2014) ISSN: 1559-131X [Electronic] United States
• PMID: 24913812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CA-125 Antigen
• MUC16 protein, human
• Membrane Proteins

Topics

• Adult
• Aged
• Brain Neoplasms (mortality, radiotherapy, secondary)
• CA-125 Antigen (blood)
• Carcinoma, Non-Small-Cell Lung (blood, mortality, pathology, radiotherapy)
• Female
• Humans
• Lung Neoplasms (blood, mortality, pathology, radiotherapy)
• Male
• Membrane Proteins (blood)
• Middle Aged
• Multivariate Analysis
• Prognosis
• Survival Rate
• Tumor Burden