Primary cutaneous nodular amyloidosis associated with psoriasis.

Abstract

Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic amyloidosis with monoclonal immunoglobulin light chain deposits. We describe a patient in whom PCNA developed in a scar in an area affected by chronic plaque psoriasis. PCNA has previously been associated with other autoimmune diseases, but to our knowledge, this is the first association with psoriasis. Interestingly, T helper (Th)17 cells, which are crucial in psoriasis pathogenesis, have recently been implicated in promotion of myeloma and plasma cell dyscrasias. The association of psoriasis and plasma-cell light chain production in the skin, as in this case, suggests a possible role for Th17 cells in PCNA formation. The dermatopathological literature of this rare but important disease is discussed.

• Authors: C Y Ung, N J Carr, M R Ardern-Jones
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 39 Issue 5 Pg. 608-11 (Jul 2014) ISSN: 1365-2230 [Electronic] England
• PMID: 24888341 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 British Association of Dermatologists.

Topics

• Adult
• Amyloidosis, Familial (pathology)
• Female
• Humans
• Psoriasis (complications)
• Skin Diseases, Genetic (pathology)