Visual outcome of mega-dose intravenous corticosteroid treatment in non-arteritic anterior ischemic optic neuropathy - retrospective analysis.

Abstract

BACKGROUND:

To date, non arteritic anterior ischemic optic neuropathy (NAION) is still incurable. We wish to evaluate the effect of intravenous (IV) corticosteroids on the visual outcome of NAION patients.

METHODS:

Visual parameters were retrospectively compared between NAION patients treated with IV corticosteroids and untreated NAION patients (control). Visual acuity (VA) and Humphrey automated static perimetry visual field (VF) defects of the affected eye were compared between groups at baseline, 1, 3, 6 months, and end of follow-up visits. The VF analysis consisted of number of quadrant involvements and mean deviation (MD).

RESULTS:

Each group comprised 23 patients (24 eyes). Mean initial VA was similar in the control and treatment groups (p = 0.8). VA at end of follow-up did not improve in either groups (p = 0.8 treated group, p = 0.1 control group). No improvement and no difference in VF defects were found by either quadrant analysis (p = 0.1 treated group, p = 0.5 control group) or MD analysis (p = 0.2, treated group, p = 0.9 control group). VA and VF parameters tended to be worse in the treated group, although without statistical significance.

CONCLUSIONS:

Our results suggest that IV corticosteroids may not improve the visual outcome of NAION patients. Since intravenous corticosteroids could potentially cause serious adverse effects, this treatment for NAION is questionable.

• Authors: Michael Kinori, Iris Ben-Bassat, Yael Wasserzug, Angela Chetrit, Ruth Huna-Baron
• Journal: BMC ophthalmology (BMC Ophthalmol) Vol. 14 Pg. 62 (May 03 2014) ISSN: 1471-2415 [Electronic] England
• PMID: 24886579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glucocorticoids

Topics

• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Glucocorticoids (administration & dosage)
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Optic Neuropathy, Ischemic (diagnosis, drug therapy, physiopathology)
• Retrospective Studies
• Time Factors
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity
• Visual Field Tests
• Visual Fields