HLA-DRA rs3129882 A/G polymorphism was not a risk factor for Parkinson's disease in Chinese-based populations: a meta-analysis.

Abstract

PURPOSE:

Many studies have evaluated the association between the HLA-DRA rs3129882 A/G polymorphism and risk for Parkinson's disease (PD) in Chinese-based populations, however, published data remain inconclusive. Therefore, we performed a meta-analysis from all relevant studies to evaluate an association of HLA-DRA rs3129882 A/G polymorphism with susceptibility to PD.

METHODS:

The summary odds ratio (OR) with its 95% confidence interval (CI) was calculated to evaluate the association. The Q statistic was used to evaluate homogeneity and funnel plots were used to assess publication bias. The minor A allele frequencies, additive, dominant as well as recessive genetic models were examined in the analyses.

RESULTS:

Five case-control studies with a total of 2230 PD cases and 2262 controls from Mainland China, Taiwan, Singapore, and Malaysia were included in the final meta-analysis. Neither the minor A allele frequencies nor the genotypic distributions were significantly different between PD cases and controls when all studies were pooled into this meta-analysis.

CONCLUSION:

The results of this meta-analysis suggest that HLA-DRA rs3129882 A/G polymorphism was not responsible for PD in Chinese-based populations.

• Authors: Ze-Gang Ma, Tian-Wei Liu, Yong-Li Bo
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 125 Issue 4 Pg. 241-6 (Apr 2015) ISSN: 1563-5279 [Electronic] England
• PMID: 24849299 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR alpha-Chains

Topics

• Asian People
• Community Health Planning
• Databases, Bibliographic (statistics & numerical data)
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• HLA-DR alpha-Chains (genetics)
• Humans
• Parkinson Disease (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors