Three ileus cases associated with the use of dipeptidyl peptidase-4 inhibitors in diabetic patients.

Abstract

Dipeptidyl peptidase (DPP)-4 inhibitors are a new class of antidiabetic drugs that increase incretin hormone levels to enhance blood sugar level-dependent insulinotropic effects, suppress glucagon action, and reduce bowel motility. These incretin effects are ideal for blood sugar control. However, the safety profile of DPP-4 inhibitors is not yet established. Herein, we present three cases of ileus, considered to be closely related to the use of DPP-4 inhibitors, in diabetic patients. Each of the three patients exhibited some risk of a deficiency in bowel movement; the onset of ileus was within 40 days after strengthened inhibition of DPP-4. The use of a DPP-4 inhibitor could be safe, although the cases presented herein enable us to inform the scientific community to some of the potential adverse effects of the use of DPP-4 inhibitors in select populations.

• Authors: Keizo Kanasaki, Kazunori Konishi, Ranji Hayashi, Hisakazu Shiroeda, Tomoe Nomura, Atsushi Nakagawa, Takako Nagai, Ai Takeda-Watanabe, Hiroki Ito, Shin-Ichi Tsuda, Munehiro Kitada, Mizue Fujii, Megumi Kanasaki, Makoto Nishizawa, Yasuharu Nakano, Yasuto Tomita, Nobuhiko Ueda, Takeo Kosaka, Daisuke Koya
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 4 Issue 6 Pg. 673-5 (Nov 27 2013) ISSN: 2040-1116 [Print] Japan
• PMID: 24843724 (Publication Type: Journal Article)