Ileus

Subscribe to Selected New Research on Ileus

1585 relevant articles (88 outcomes, 119 trials/studies) found for this Disease

Description: A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 31

Gastrointestinal Diseases: 1230

Intestinal Diseases: 601

Intestinal Obstruction: 1203

Ileus: 1585

Intestinal Pseudo-Obstruction: 482

Related Diseases

1.	Pain (Aches)
2.	Vomiting
3.	Nausea
4.	Postoperative Pain
5.	Constipation

Experts

1.	Bauer, Anthony J: 5 articles (12/2006 - 02/2003)
2.	Moore, Beverley A: 5 articles (08/2006 - 02/2003)
3.	Du, Wei: 4 articles (04/2007 - 10/2004)
4.	Techner, Lee: 4 articles (04/2007 - 10/2004)
5.	Sein-Anand, J: 3 articles (11/2007 - 03/2004)
6.	Wolff, Bruce G: 3 articles (04/2007 - 10/2004)
7.	Delaney, Conor P: 3 articles (04/2007 - 06/2005)
8.	Türler, Andreas: 3 articles (08/2006 - 02/2003)
9.	Korolkiewicz, Roman P: 2 articles (07/2008 - 02/2003)
10.	Weese, James L: 2 articles (04/2007 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ileus:

1.	alvimopan FDA Link 10/01/2005 - "Alvimopan is effective in treating postsurgical ileus and perhaps opiate-induced bowel dysfunction. " 09/01/2007 - "Is alvimopan a safe and effective treatment for postoperative ileus?" 01/01/2008 - "The efficacy of alvimopan in the management of postoperative ileus has been evaluated in five phase III trials; four conducted in North America and one conducted in Europe/Australasia. " 08/01/2008 - "Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study." 05/01/2008 - "Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials." Order ALL the reference details at left...
2.	Cisapride (Propulsid)FDA Link 09/01/1997 - "CONCLUSION: Cisapride is effective in neonates with a prolonged ileus after abdominal surgery." 06/01/1989 - "Cisapride appears safe and effective in the prophylaxis of equine post operative ileus." 07/01/1987 - "This study suggests that cisapride in repeated dosage may be of value in inducing remission in prolonged surgical ileus, particularly in patients who have undergone intraperitoneal operations." 09/01/1997 - "AIM: To assess the efficacy of cisapride in reducing ileus persisting to the tenth postoperative day after neonatal abdominal surgery. " 09/01/1997 - "Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial." Order ALL the reference details at left...
3.	Metoclopramide (Reglan)FDA LinkGeneric 10/01/2001 - "STUDY OBJECTIVE: To assess the efficacy of metoclopramide for treatment of postoperative ileus in patients who underwent exploratory laparatomy. " 10/01/1996 - "Efficacy of metoclopramide for treatment of ileus in horses following small intestinal surgery: 70 cases (1989-1992)." 04/01/1986 - "In a double blind controlled study including 60 patients it was found that Metoclopramide has a negative effect upon the resolution of postoperative adynamic ileus. " 10/01/2001 - "Metoclopramide does not have a role in the treatment of postoperative ileus." 02/01/2000 - "PURPOSE: To assess the feasibility and complications of the laparoscopic approach to anterior lumbar fusion and to evaluate the ability of metoclopramide in conjunction with preoperative bowel preparation and early oral feeding to decrease postoperative ileus and reduce the length of hospital stay. " Order ALL the reference details at left...
4.	Neostigmine (Neostigmine Bromide)IBA 12/01/2001 - "Theoretically, it may be useful in reversing anticholinergic ileus resulting from acute drug overdose, allowing or enhancing decontamination, but the safety and potential efficacy of neostigmine in this scenario have not been established." 01/01/1989 - "Further, neostigmine did not adversely affect intestinal hemodynamics while increasing rhythmic contractions, suggesting that neostigmine may be useful in the treatment of ileus in equids." 03/01/2008 - "In this study, we evaluated the effect of epidurally administered neostigmine on postoperative ileus after abdominal aortic surgery. " 12/01/2001 - "This study is a prospective clinical trial of neostigmine in seven spinal patients with ileus after surgery to demonstrate its efficacy. " 03/01/2008 - "CONCLUSIONS: Thoracic epidural neostigmine enables faster restoration of bowel sounds and shortens duration of postoperative ileus after abdominal aortic surgery." Order ALL the reference details at left...
5.	Carbon MonoxideIBA 02/01/2003 - "This study examined whether inhaled CO was protective against the development of postoperative ileus. " 12/01/2006 - "These data support the view that a single intraperitoneal dose of CO-LR ameliorates postoperative ileus in mice by inhibiting the inflammatory response in the gut wall induced by surgical manipulation, possibly in a sGC-dependent fashion." 03/01/2009 - "BACKGROUND AND AIMS: Treatment with carbon monoxide (CO) inhalation has been shown to ameliorate postoperative ileus (POI) in rodents and swine. " 03/01/2009 - "Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress." 06/01/2005 - "Carbon monoxide and ileus: inhaled gas to prevent retained gas?" Order ALL the reference details at left...
6.	Chewing Gum (Chewing Gums)IBA 01/01/2008 - "BACKGROUND: Recent trials have shown promising results for the efficacy of gum chewing for the amelioration of postoperative ileus. " 04/01/2009 - "We evaluated the efficacy of gum chewing in the treatment of ileus after elective colorectal surgery. " 01/01/2008 - "A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus." 12/01/2007 - "This study was designed to conduct a systematic review of all relevant trials on chewing gum to reduce postoperative ileus after colorectal resection. " 05/01/2006 - "CONCLUSIONS: In contrast to findings of a preliminary study, our clinical trial suggests that gum chewing, although safe, does not reduce duration of postcolectomy ileus." Order ALL the reference details at left...
7.	Opioid Analgesics (Opioids)IBA 01/01/2001 - "Measures to limit the use of opioids may be effective in shortening the duration of postoperative ileus in newborn infants." 01/01/2002 - "The pathogenesis of postoperative ileus (PI) is multifactorial, and includes activation of inhibitory reflexes, inflammatory mediators and opioids (endogenous and exogenous). " 11/01/2001 - "Recently, the potential influence of endogenous opioids, in addition to exogenous opioids, on the pathogenesis of ileus has come to light and spurred investigations into new treatment strategies. " 11/01/2001 - "The use of postoperative opioids also appears to contribute to ileus. " 01/01/2001 - "The use of opioids is associated with delayed resolution of ileus. " Order ALL the reference details at left...
8.	MotilinIBA 01/01/1976 - "In this study, the effect of 13-norleucine motilin (13-Nle-M) on post-cholecystectomy ileus was assessed in 6 female patients. " 07/28/2000 - "The aim of this study was to investigate the effect of SK-896 (Phe-Val-Pro-Ile-Phe-Thr-Try-Gly-Glu-Leu-Gln-Arg-Leu-Gln-Glu-Lys-Glu- Arg-Asn-Lys-Gly-Gln-Hse), a new motilin analogue, on gastrointestinal motility and transit in dogs with post-operative ileus, and to compare the effects of this agent on these parameters with the effects of prostaglandin F(2alpha), a well-known gastroprokinetic agent. " 08/01/2002 - "The effects of SK-896, a new human motilin analogue ([Leu13]motilin-Hse), on digestive tract motility in postoperative ileus were evaluated in a dog model of ileus after laparotomy. " 08/01/2002 - "Effects of SK-896, a new human motilin analogue ([Leu13]motilin-Hse), on postoperative ileus in dogs after laparotomy." 08/01/2009 - "Ghrelin agonists have the same potential as motilin agonists to treat hypomotility disorders but their effects on appetite may even be a bonus to treat disorders such as functional dyspepsia while ghrelin's anti-inflammatory effects may make it superior to motilin to treat post-operative ileus. " Order ALL the reference details at left...
9.	methylnaltrexone FDA Link 01/01/2008 - "The intravenous formulation of methylnaltrexone is currently in phase III clinical trials for the potential treatment of postoperative ileus." 10/01/2009 - "Although it is not the focus of this article, methylnaltrexone's mechanism of action suggests it could be beneficial for other peripheral, opioid-induced adverse effects, such as opioid-related nausea, vomiting, urinary retention, pruritus or postoperative ileus." 09/01/2008 - "Methylnaltrexone, a new peripherally acting mu-opioid receptor antagonist being evaluated for the treatment of postoperative ileus." 11/01/2007 - "Currently there are two compounds, N-methylnaltrexone and alvimopan, under FDA review as possible treatments for opioid induced bowel dysfunction and postoperative ileus. " 01/01/2007 - "Methylnaltrexone and alvimopan are two new and potentially useful agents in the management of opioid-induced bowel dysfunction and prevention of postoperative ileus. " Order ALL the reference details at left...
10.	Erythromycin (Erycette)FDA LinkGeneric 02/01/1993 - "We attempted to determine whether the administration of erythromycin shortens the period of postoperative ileus by a prospective, double-blind, placebo-controlled study. " 07/01/2008 - "Use of erythromycin in prevention or treatment of postoperative ileus." 04/01/2007 - "Treatment of postoperative ileus after bowel surgery with low-dose intravenous erythromycin." 02/01/1993 - "Effect of intravenous erythromycin on postoperative ileus." 10/01/1988 - "The temporal association with erythromycin therapy, resolution of signs and symptoms when the drug was stopped, an uneventful recovery, and the absence of other causes, suggest a possible role of erythromycin in the pathogenesis of dynamic ileus in these patients. " Order ALL the reference details at left...

Therapies and Procedures

1.	Enema (Enemas) 10/01/2007 - "BACKGROUND: Although administration of a water-soluble contrast enema has been recognized to be effective for meconium-related ileus, there have been no definitive management guidelines for very low-birthweight infants. " 10/01/2007 - "CONCLUSION: Although administration of water-soluble contrast enemas can be effective for meconium-related ileus, reflux into the terminal ileum is essential for bowel obstruction to improve, so it is desirable to perform the procedure under fluoroscopic guidance." 04/01/1997 - "Meconium ileus obstruction may be relieved medically by contrast enema; ileal atresia requires prompt surgical intervention. " 02/01/1970 - "Meconium ileus relieved by 40 per cent water-soluble contrast enemas." 10/01/2005 - "Fifteen of 42 (36%) babies with simple meconium ileus (MI) were treated nonoperatively with hypertonic enemas, 27 of 42 and all 45 patients with complicated MI required operation, including 15 with jejunoileal atresia (17%). " Order ALL the reference details at left...
2.	Laparotomy 11/01/2008 - "After the general condition was improved, operation was performed for sub-ileus in March, but it became a probe laparotomy for severe peritoneal dissemination. " 09/26/1975 - "The existing subileus or ileus condition can be eliminated in all cases by stretching the sphincter and partial sphincterotomy, so that the patients could be spared a laparotomy." 08/01/2009 - "Patients with a history of meconium ileus or previous laparotomy are at high risk of developing DIOS. " 08/01/2009 - "The development of DIOS was significantly associated with a past history of meconium ileus (odds ratio 20.7, 95% C.I. 5.09-83.9) or previous laparotomy (odds ratio 4.93, 95% C.I. 1.47-16.6). " 01/01/2009 - "This approach is associated with an increased operative time compared to laparotomy, however, offers significant advantages over open ileocolic resection in terms of pulmonary function, length of hospital stay, duration of postoperative ileus, cosmesis, postoperative small bowel obstruction, and early postoperative complications. " Order ALL the reference details at left...
3.	Colectomy 02/01/2000 - "The aim of this study was to determine whether return of bowel function after colectomy is directly related to narcotic use and to evaluate the effect of incision length on postoperative ileus. " 07/01/2009 - "CONCLUSION: Postoperative ileus in colectomy patients is a significant predictor of hospital resource utilization." 07/01/2009 - "A majority of the colectomy patients with and without postoperative ileus, respectively, were male (54.1% vs. 50.3%, P < 0.001), Caucasian (70.5% vs. 69.3%, P = 0.170), and aged 51-64 years (51.1% vs. 49.7%, P = 0.143). " 07/01/2009 - "Code 997.4 was used to account for cases in which postoperative ileus would be reported as a complication of anastomosis, as could be the case in colectomy surgeries. " 07/01/2009 - "OBJECTIVE: To assess health care utilization and costs in colectomy surgery patients who developed postoperative ileus versus those who did not. " Order ALL the reference details at left...
4.	Analgesia 06/01/2007 - "CONCLUSION: Despite improved analgesia and a decrease in ileus, EA has some adverse effects and does not shorten the duration of hospital stay after colorectal surgery." 10/01/2008 - "'Fast-track' recovery protocols, opioid sparing analgesia, and laparoscopic surgery reduce but do not eliminate postoperative ileus. " 09/01/2004 - "Under escalating opiate dosages, the patient had developed persistent ileus as well as abdominal distension that caused respiratory compromise, without receiving sufficient analgesia. " 07/01/2003 - "CONCLUSIONS: Laparoscopic surgery in DD is feasible, safe, requires less analgesia and allows a faster recovery of post-operative ileus and a lower hospital stay." 01/01/2003 - "BACKGROUND AND AIMS: Peridural analgesia (PDA) is a common treatment in postoperative management after abdominal surgery to shorten postoperative ileus and to permit early postoperative nutrition. " Order ALL the reference details at left...
5.	Epidural Analgesia 05/01/1977 - "It appears that high epidural analgesia may be useful in the treatment of postoperative adynamic ileus." 09/01/2007 - "Well designed randomized controlled trials (RCT's) have also shown that epidural analgesia reduces the duration of ileus after colorectal surgery. " 10/01/1999 - "BACKGROUND: The aim of the study was to evaluate whether perioperative epidural analgesia had any effect on the duration of postoperative ileus after laparoscopic sigmoid resection. " 07/01/2008 - "Pancreatic fistulae and postoperative ileus occurred more frequently, and patients with epidural analgesia more often required discharge to rehabilitation facilities. " 04/01/2008 - "Based on many clinical and basic reports that affirm the effect on the recovery of gastrointestinal motility, epidural analgesia has been used widely to promote recovery from postoperative ileus. " Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Ileus

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 88 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>