Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study.

Abstract

OBJECTIVES:

To explore the expression patterns of Eag1 (ether á go-go 1) and HIF-1α (hypoxia-inducible factor 1α) in a cohort of patients with breast cancer.

SETTING:

Department of general surgery in an upper first-class hospital in Xi'an, China.

PARTICIPANTS:

A total of 112 female Han Chinese patients with a diagnosis of invasive ductal carcinoma were included. Patients with main internal diseases, such as cardiovascular, endocrine, gastroenterological, haematological, infectious diseases, etc, were excluded.

PRIMARY AND SECONDARY OUTCOME MEASURES:

Expression profiles of Eag1 and HIF-1α.

RESULTS:

Eag1 and HIF-1α were overexpressed in the tumour tissues compared with the pair-matched control tissues, p=0.002 and <0.001, respectively. The expression of Eag1 and HIF-1α was negatively correlated with tumour size, p=0.032 and p=0.025, respectively, and lymph node status (p=0.040, p=0.032, respectively). The coexpression of Eag1 and HIF-1α was correlated with tumour size (p=0.012), lymph node status (p=0.027) and tumour stage (p=0.036). HIF-1α has a strong correlation with hEag1 expression (κ=0.731, p<0.001).

CONCLUSIONS:

HIF-1α expression has a strong correlation with hEag1 expression. We are the first to attempt to explore the correlation at the population level.

• Authors: Qingxuan Lai, Ting Wang, Qingqing Guo, Yuxiang Zhang, Youxin Wang, Li Yuan, Rui Ling, Yan He, Wei Wang
• Journal: BMJ open (BMJ Open) Vol. 4 Issue 5 Pg. e005049 (May 16 2014) ISSN: 2044-6055 [Print] England
• PMID: 24838727 (Publication Type: Journal Article, Observational Study)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Chemical References

• Biomarkers, Tumor
• Ether-A-Go-Go Potassium Channels
• HIF1A protein, human
• Hypoxia-Inducible Factor 1, alpha Subunit
• KCNH1 protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (biosynthesis)
• Breast Neoplasms (diagnosis, metabolism)
• Ether-A-Go-Go Potassium Channels (biosynthesis)
• Female
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (biosynthesis)
• Immunohistochemistry
• Middle Aged
• Prognosis
• Young Adult