Protein expression of hypoxia-inducible factor-1 alpha and hepatocellular carcinoma: a systematic review with meta-analysis.

Abstract

PURPOSE:

To investigate the relationship of protein expression of hypoxia-inducible factor-1 alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC).

METHODS:

PubMed and Embase were searched from their inception through August 2013 for studies that reported the association between protein expression of HIF-1α and HCC. Random effects meta-analyses were used to summarize the odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS:

Eight studies involving 851 patients with HCC were included. Protein expression level of HIF-1α was not found to be related with capsule formation, cirrhosis, tumor size, and tumor differentiation of HCC, except vascular invasion. The positive association between HIF-1α expression and vascular invasion of HCC was statistically significant (OR: 2.04, 95% CI: 1.31-3.18). As a prognostic factor, a high level of HIF-1α expression would be associated with a poor disease-free survival (OR: 2.10, 95% CI: 1.48-2.97).

CONCLUSION:

Higher level of HIF-1α expression may indicate a bigger possibility of vascular invasion and a poorer prognosis of HCC.

• Authors: Shiyi Cao, Shengli Yang, Chao Wu, Yunxia Wang, Jianxin Jiang, Zuxun Lu
• Journal: Clinics and research in hepatology and gastroenterology (Clin Res Hepatol Gastroenterol) Vol. 38 Issue 5 Pg. 598-603 (Oct 2014) ISSN: 2210-741X [Electronic] France
• PMID: 24835771 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Chemical References

• Hypoxia-Inducible Factor 1, alpha Subunit

Topics

• Carcinoma, Hepatocellular (metabolism)
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (biosynthesis)
• Liver Neoplasms (metabolism)