Abstract | BACKGROUND: METHODS: A total of 130 patients were divided into high- glucose (HG), low- glucose (LG) and control group according to the preoperative level of blood glucose. The expression of ECM-related genes was analysed by microarray. RESULTS: Compared with control group, 30 genes showed at least a threefold change in expression in HG group; up-regulation was observed in 24 genes. However, there were only 21 ECM-related genes showed at least a threefold change in expression between the LG and control group. Compared with HG group, matrix metalloproteinases' ( MMPs) expression was significantly decreased in LG and control groups. In contrast to the decrease in MMPs' expression, expression of tissue inhibitors of metalloproteinases (TIMPs) was increased. CONCLUSION: This study suggested that different preoperative diabetic status affected the expression of ECM-related genes in SV. ECM-related genes were more significantly imbalanced in diabetic patients with uncontrolled preoperative blood glucose than those with well-controlled preoperative blood glucose.
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Authors | Yongxin Sun, Zibo Lin, Wenjun Ding, Qiang Wei, Yunqing Shi, Chunsheng Wang |
Journal | Diabetes & vascular disease research
(Diab Vasc Dis Res)
Vol. 11
Issue 4
Pg. 226-234
(Jul 2014)
ISSN: 1752-8984 [Electronic] England |
PMID | 24781271
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2014. |