Immunohistochemical expressions of
keratin polypeptides detected by
monoclonal antibodies were described in
tumor cells of
adenolymphoma, and the possibility of intercalated duct and ductal basal cells in the salivary glands being the progenitors was discussed. Basal cells in the
tumor showed positive staining for
keratin nos. 8, 13, 16, 18 and 19 detecting for monoclonal
keratin antibodies (PKK 1, K 4.62, K 8.12, K 8.13), columnar
tumor cells displayed strongly positive reactions with RPN 1164 and K4.62 suggesting
keratin nos. 8 and 19. Great heterogeneity of distribution for
keratin polypeptides was displayed by epithelial cells of
adenolymphoma. Intercalated duct cells of normal salivary glands reacted with RPN 1164, RPN 1165, K 4.62 and K 8.13
monoclonal antibodies, which indicates the presence of
keratins 8 and 19; and ductal basal cells reacted with PKK 1, K 4.62 and K 8.12, suggesting nos. 8, 13, 16, 18 and 19
keratins. Distribution of
involucrin was variable in
tumor epithelium of
adenolymphoma, and was negative in the normal gland. The immunohistochemical distribution of
keratin types between basal
tumor cells of
adenolymphoma and ductal basal cells of the normal salivary gland was compared.