[Clinical analysis of 81 cases of malignant lymphoma treated with autologous hematopoietic stem cell transplantation].

Abstract

OBJECTIVE:

To investigated the curative effect of autologous hematopoietic stem cell transplantation (ASCT) for malignant lymphoma.

METHODS:

The clinical data of 81 patients with malignant lymphoma received ASCT from April 1999 to October 2013 were retrospectively analyzed. Of 81 patients, 70 were non-Hodgkin's lymphoma (NHL) and 11 Hodgkin's lymphoma (HL). High dose of etoposide combined with G-CSF was used to mobilize peripheral hematopoietic stem cell. Preconditioning regimen was BEAM (carmustine + cytarabine + etoposide + melphalan).

RESULTS:

Enough peripheral blood stem cells were collected from all patients. All of the patients after transplantation achieved hematopoietic reconstitution, the median time of the absolute neutrophil count (ANC) recovery to >0.5×10⁹/L time was 10(7-16) d, and the median time of platelet count recovery to >20×10⁹/L was 10(6-17) d. With the follow-up of 23(2-139) months, progression free survival (PFS) was 72.7%, and overall survival (OS) was 88.6%. The median PFS and OS were not reached. Complete remission (CR) before ASCT was an independent prognostic factor of PFS. No transplant related death happened.

CONCLUSION:

ASCT was a safe and effective method for treatment of malignant lymphoma.

• Authors: Li Wang, Lei Fan, Kourong Miao, Ji Xu, Run Zhang, Ming Hong, Huayuan Zhu, Wenyi Shen, Xiaoyan Zhang, Lijuan Chen, Hongxia Qiu, Hua Lu, Peng Liu, Hanxin Wu, Wei Xu, Jianyong Li
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 35 Issue 4 Pg. 328-31 (Apr 2014) ISSN: 0253-2727 [Print] China
• PMID: 24759022 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Lymphoma (therapy)
• Male
• Middle Aged
• Retrospective Studies
• Transplantation, Autologous