Abstract |
Waldenström's macroglobulinemia (WM) is an indolent lym phomaand is responsive to therapy regimens containing alkylating agents, purine analogs and rituximab if treatment becomes necessary. We initiated a multicenter phase II trial to determine the safety and efficacy of a regimen containing pentostatin, cyclophosphamide and rituximab (PER) in patients with WM. Between May 2005 and December 2010, 25 patients with WM were included in the study. Twenty-one patients received PER as first-line therapy. In these patients, 2-year progression-free survival was 83.6% and 2-year overall survival was 100%. Thirteen patients (52%) received R maintenance therapy. In these patients, the 2-year progression-free survival was 91.67% and 2-year overall survival was 100%. We have provided evidence that PER is a safe and effective regimen for WM. Although R maintenance therapy after PER seemed to induce a better long-term outcome, this study was not powered to address this issue.
|
Authors | Isabelle Herth, Manfred Hensel, Michael Rieger, Kristin Horstmann, Wolfgang Hiddemann, Martin Dreyling, Silvia Koniczek, Mathias Witzens-Harig, Anthony D Ho |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 56
Issue 1
Pg. 97-102
(Jan 2015)
ISSN: 1029-2403 [Electronic] United States |
PMID | 24724778
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study)
|
Chemical References |
- Antibodies, Monoclonal, Murine-Derived
- Pentostatin
- Rituximab
- Cyclophosphamide
|
Topics |
- Adult
- Aged
- Antibodies, Monoclonal, Murine-Derived
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Cyclophosphamide
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Pentostatin
(administration & dosage)
- Rituximab
- Treatment Outcome
- Waldenstrom Macroglobulinemia
(diagnosis, drug therapy, mortality)
|