Studies of protease inhibitors in the sera of patients with amyotrophic lateral sclerosis.

Abstract

Serum levels of 4 protease inhibitors, alpha-1-antitrypsin, C1-inactivator, alpha-2-macroglobulin and antithrombin-III were measured in 11 patients with amyotrophic lateral sclerosis (6 males and 5 females) and a control group without neurologic disease. Our results indicated no significant differences in the level of serum alpha-2-macroglobulin between the 2 groups. We found slight but significantly lower levels of serum antithrombin-III in ALS. The possibility of the participation of proteases or protease inhibitors in the pathogenesis of ALS is discussed.

• Authors: N Adachi, S Shoji
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 89 Issue 2-3 Pg. 165-8 (Feb 1989) ISSN: 0022-510X [Print] Netherlands
• PMID: 2466958 (Publication Type: Journal Article)

Chemical References

• Protease Inhibitors
• alpha 1-Antitrypsin
• alpha-Macroglobulins
• Antithrombin III

Topics

• Amyotrophic Lateral Sclerosis (blood)
• Antithrombin III (blood)
• Female
• Humans
• Male
• Protease Inhibitors (blood)
• alpha 1-Antitrypsin (blood)
• alpha-Macroglobulins (blood)