Abstract | BACKGROUND: METHODS: RESULTS: Systolic blood pressure significantly decreased from 139.5 mm Hg (baseline) from 128.7 mm Hg (at 3 months), whereas no significant changes were observed for diastolic blood pressure. The percentage of patients achieving the target level of antihypertensive effect (blood pressure < 130/80 mm Hg) significantly improved from 30.0% (baseline) to 70.0% (at 3 months). No significant changes were observed in renal graft function, oxidative stress marker level, or biochemical examination findings. CONCLUSION: Sufficient antihypertensive effect was demonstrated soon after switching to azilsartan. However, no significant change was found in renal damage markers. Long-term study must be conducted to confirm the protective effect azilsartan on the transplanted kidney, as found with candesartan. The safety of azilsartan was demonstrated. If the transplanted kidney protection is demonstrated, this drug is expected to contribute to the improved long-term prognosis of renal transplant recipients.
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Authors | T Ishii, M Yasuda, Y Saito, Y Mori, T Hayashi, H Uemura, K Nose, T Nishioka |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 46
Issue 2
Pg. 492-5
( 2014)
ISSN: 1873-2623 [Electronic] United States |
PMID | 24655997
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Antihypertensive Agents
- Benzimidazoles
- Biphenyl Compounds
- Oxadiazoles
- Tetrazoles
- Creatinine
- azilsartan
- candesartan
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Topics |
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Biphenyl Compounds
- Creatinine
(blood)
- Female
- Humans
- Kidney Transplantation
- Male
- Oxadiazoles
(therapeutic use)
- Tetrazoles
(therapeutic use)
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