Abstract | BACKGROUND: METHODS: We analyzed the records of 118 patients referred to Chang Gung Memorial Hospital for management of intentional organophosphate poisoning between 2000 and 2011. Patients were stratified by diabetes mellitus status. Demographic, clinical, laboratory and mortality data were analyzed. RESULTS: Most patients were middle aged (53.45 ± 16.20 years) and male (65.3%) and were referred to our hospital after a relatively short amount of time had elapsed since poisoning (median 3.0 hours). 18 (15.2%) of 118 patients died, including 15 (13.8%) of 109 patients without diabetes mellitus and 3 (33.3%) of 9 with diabetes mellitus. There was no significant difference in mortality between these groups (P = 0.117). In a multivariate Cox regression model, hypotension (P = 0.000), respiratory failure (P = 0.042), coma (P = 0.023), and corrected QT interval prolongation (P = 0.002) were significant risk factors for mortality. Conversely, diabetes mellitus status was not a significant variable in this model. At routine outpatient follow up a median of 1.25 months post exposure, random blood glucose measurements gave no evidence of new-onset diabetes in patients without pre-existing diabetes. CONCLUSIONS:
Diabetes mellitus status might not increase mortality risk following acute large-dose exposure to organophosphates, and the risk of new-onset diabetes mellitus also might be minimal in the short term. Larger prospective studies with formal testing for diabetes at later times post-exposure are required.
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Authors | Shou-Hsuan Liu, Ja-Liang Lin, Hsin-Lan Shen, Chih-Chun Chang, Wen-Hung Huang, Cheng-Hao Weng, Ching-Wei Hsu, I-Kuan Wang, Chih-Chia Liang, Tzung-Hai Yen |
Journal | Environmental health : a global access science source
(Environ Health)
Vol. 13
Issue 1
Pg. 11
(Mar 06 2014)
ISSN: 1476-069X [Electronic] England |
PMID | 24597539
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Insecticides
- Cholinesterases
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Topics |
- Adult
- Aged
- Blood Glucose
(analysis)
- Cholinesterases
(blood)
- Diabetes Mellitus
(blood, mortality)
- Female
- Humans
- Insecticides
(poisoning)
- Male
- Middle Aged
- Organophosphate Poisoning
(blood, mortality)
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