The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan.

Abstract

BACKGROUND:

Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan.

METHODS:

3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) <100 mg/dl, high-density lipoprotein (HDL) > 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl.

RESULTS:

Compared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019).

CONCLUSION:

Although presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects.

• Authors: Tsung-Hsien Lin, Shao-Yuan Chuang, Chun-Yuan Chu, Wen-Hsien Lee, Po-Chao Hsu, Ho-Ming Su, Yi-Heng Li, Ching-Chang Fang, Kuo-Yang Wang, Wei-Kung Tseng, Ai-Hsien Li, Kwo-Chang Ueng, I-Chang Hsieh, Lien-Chi Huang, Chiun-Hsiung Wang, Wen-Harn Pan, Hung-I Yeh, Chau-Chung Wu, Wei-Hsian Yin, Jaw-Wen Chen
• Journal: International journal of medical sciences (Int J Med Sci) Vol. 11 Issue 4 Pg. 381-8 ( 2014) ISSN: 1449-1907 [Electronic] Australia
• PMID: 24578616 (Publication Type: Journal Article)

Chemical References

• Lipoproteins, HDL
• Lipoproteins, LDL
• Triglycerides

Topics

• Atherosclerosis (blood, metabolism)
• Cross-Sectional Studies
• Female
• Humans
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Male
• Multivariate Analysis
• Renal Insufficiency, Chronic (blood, metabolism)
• Taiwan
• Triglycerides (blood)